Diethylene Glycol Monomethyl Ether → HCID 104568219, compound

Participants

Reaction Conditions

Reaction Steps

28.9 g (0.20 mol) of 2,4-diamino-6-chloropyrimidine was added to a solution of 4.6 g (0.20 mol) of sodium in 178 ml of 2-(2-methoxyethoxyl)ethanol and heated to 80° C. for 48 h while stirring was performed. After termination of the reaction, the precipitated NaCl was separated and the solution was concentrated to dryness. The residue was taken in ethanol multiple times and concentrated again in order to remove remaining 2-(2-methoxyethoxyl)ethanol. After drying, 6-[2-(2-methoxyethoxyl)ethoxy]pyrimidine-2,4-diamine (49.8 g, 109%) was obtained as brown oil, which still contained 2-(2-methoxyethoxyl)ethanol as a contaminant.

Provenance & Evidence