Hydrochloric Acid → HCID 131735717, compound

Participants

Reaction Steps

1.5 g (0.04 mol %) of palladium on carbon (5%) was added to a solution of 11.3 g (0.044 mol) of 6-[2-(2-methoxyethoxyl)ethoxy]-5-nitrosopyrimidine-2,4-diamine from step 5.2 in 400 ml of ethanol, and shaking was performed at room temperature for 16 h under hydrogen-1 atmosphere. Then the reaction mixture was poured into 80 ml of diluted hydrochloric acid (0.23 mol), the catalyst was filtered off, and the filtrate was concentrated almost to dryness. The precipitated crystals were sucked off and post-washed with ethanol. 6-[2-(2-methoxyethoxyl)ethoxy]pyrimidine-2,4,5-triamine, dihydrochloride (11.7 g, 84%) was obtained as white crystals.

Provenance & Evidence