HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 2201397Generated: October 29, 2026
Hydrochloric Acid → N-(3-chloroquinoxalin-2-yl)-3-nitrobenzenesulfonamide
https://huagongshe.com/reaction/2201397
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Hydrochloric Acid | HCID 313 | — |
| Reactant | 2,3-Dichloroquinoxaline | HCID 16659 | — |
| Reactant | Benzenesulfonamide, 3-nitro- | HCID 67138 | — |
| Reactant | 1,8-Diazabicyclo(5.4.0)undec-7-ene | HCID 81184 | — |
| Solvent | Methanol | HCID 887 | — |
| Solvent | Acetonitrile | HCID 6342 | — |
| Product | N-(3-chloroquinoxalin-2-yl)-3-nitrobenzenesulfonamide | HCID 5007601 | — |
Reaction Steps
1 kg of 2,3 dichloroquinoxaline and 1 kg of 3-nitrobenzenesulfonamide are mixed in 5 volumes of acetonitrile. The reaction mixture is heated to reflux. 2.3 kg of DBU and 1 volume of acetonitrile are added. After completion of the reaction, cool down at 5° C. Add 12 volumes of methanol and 1.53 kg of HCl, filter the reaction mixture. Wash the cake with 6 volumes of methanol and dry under vacuum.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| Patent number | US09364475B2 |
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| Source dataset | uspto-grants-2016_06 |
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| ORD ID | ord-d7a87ec68b324d1fbeb566400d40011a |
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| Source note | uspto-grants-2016_06 |
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