HuagongsheHuagongshe Chemistry Print Report · For research reference only
4-Carboxy-3-fluorophenylboronic acid → 2-Fluoro-4-(6-hydroxyquinolin-2-yl)benzoic acid
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 4-Carboxy-3-fluorophenylboronic acid | HCID 2763201 | — |
| Reactant | 2-Chloroquinolin-6-ol | HCID 22132577 | — |
| Product | 2-Fluoro-4-(6-hydroxyquinolin-2-yl)benzoic acid | HCID 56960914 | — |
Reaction Steps
Followed Scheme 3: Starting Materials: 2-chloroquinolin-6-ol (Intermediate 2) and 4-borono-2-fluorobenzoic acid. 1H NMR (CD3OD, 400 MHz): δ 8.54 (d, J=8.4 Hz, 1H), 8.20-8.06 (m, 3H), 8.06-7.96 (m, 2H), 7.55 (dd, J=9.2, 2.4 Hz, 1H), 7.32 (d, J=2.8 Hz, 1H). MS (ESI): m/z 283.6 [M+1]+.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US09364481B2 |
| Source dataset | uspto-grants-2016_06 |
| ORD ID | ord-df3e46704f864ce982f6a5abef494cde |
| Source note | uspto-grants-2016_06 |