HuagongsheHuagongshe Chemistry Print Report · For research reference only
2,4-Dichloro-6-methoxyquinoline → 4-(4-Chloro-6-methoxyquinolin-2-yl)benzonitrile
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 2,4-Dichloro-6-methoxyquinoline | HCID 948356 | — |
| Reactant | 4-Cyanophenylboronic acid | HCID 2734326 | — |
| Catalyst | HCID 178418397 | HCID 178418397 | — |
| Solvent | Dimethylformamide | HCID 6228 | — |
| Product | 4-(4-Chloro-6-methoxyquinolin-2-yl)benzonitrile | HCID 66980050 | — |
Reaction Conditions
| Temperature | 100 °C |
|---|
Reaction Steps
Followed Scheme 2, Step 1 starting from 4-cyanophenylboronic acid and 2,4-dichloro-6-methoxyquinoline, where the solvent used was DMF, and the catalyst used was Pd(PPh3)4, The mixture was heated to 100° C. for 3 h, allowed to cool, and then poured into ice water. The resulting solid was isolated by filtration, washed with water, and dried followed by recrystallization from methanol to give the desired product.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US09364481B2 |
| Source dataset | uspto-grants-2016_06 |
| ORD ID | ord-e10ea7832af3459daeded765e47b3b1f |
| Source note | uspto-grants-2016_06 |