HuagongsheHuagongshe Chemistry Print Report · For research reference only
Water → 4-(6-Hydroxyquinolin-2-yl)benzonitrile
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Water | HCID 962 | — |
| Reactant | 1,4-Dioxane | HCID 31275 | — |
| Reactant | 4-Cyanophenylboronic acid | HCID 2734326 | — |
| Reactant | 2-Chloroquinolin-6-ol | HCID 22132577 | — |
| Solvent | Ethyl Acetate | HCID 8857 | — |
| Product | 4-(6-Hydroxyquinolin-2-yl)benzonitrile | HCID 66980094 | — |
Reaction Steps
Followed Scheme 3 starting from 2-chloroquinolin-6-ol (Intermediate 2) and 4-cyanophenylboronic acid, and using 1,4-Dioxane:H2O solution. Reaction was run at 100° C. in a microwave reactor for 1 hour. Ethyl acetate workup was followed by column chromatography (5% to 50% EtOAc in hexanes gradient).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US09364481B2 |
| Source dataset | uspto-grants-2016_06 |
| ORD ID | ord-6d8e7369982d440fb94fa413ca6a9b55 |
| Source note | uspto-grants-2016_06 |