HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 2201466Generated: October 29, 2026
Potassium Carbonate → HCID 67974883, compound
https://huagongshe.com/reaction/2201466
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Potassium Carbonate | HCID 11430 | — |
| Reactant | [4-(2H-Tetrazol-5-yl)phenyl]boronic acid | HCID 46737995 | — |
| Reactant | HCID 53212388 | HCID 53212388 | — |
| Catalyst | Bis(cyclopenta-1,4-dien-1-yl(diphenyl)phosphane);dichloropalladium;iron(2+) | HCID 178418228 | — |
| Solvent | Water | HCID 962 | — |
| Solvent | Diethylene Glycol Monomethyl Ether | HCID 8134 | — |
| Product | HCID 67974883 | HCID 67974883 | 79.1% |
Reaction Steps
2-chloro-6-methoxy-3-(trifluoromethyl)quinoxaline (Intermediate 11, 321 mg) was treated with (4-(2H-tetrazol-5-yl)phenyl)boronic acid (256 mg), K2CO3 (338 mg) and PdCl2(dppf) (27 mg) in diethylene glycol methyl ether (3 mL) and water (0.8 mL) in a sealed microwave tube and heated at 120° C. with microwave for 1.5 h. The resultant mixture was diluted with water (20 mL) and acidifed to pH 4 to precipitate the desired product. The solids were collected by filtration, dried under vacuum and trituated with DCM to give 360 mg of gray solid.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| Patent number | US09364481B2 |
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| Source dataset | uspto-grants-2016_06 |
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| ORD ID | ord-bb597fedad9a4af9aa138619d7cf2143 |
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| Source note | uspto-grants-2016_06 |
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