HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 2201467Generated: October 29, 2026
Ethyl 4-piperidinecarboxylate → HCID 67974345, compound
https://huagongshe.com/reaction/2201467
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Ethyl 4-piperidinecarboxylate | HCID 70770 | — |
| Reactant | HCID 53212388 | HCID 53212388 | — |
| Solvent | Acetonitrile | HCID 6342 | — |
| Product | HCID 67974345 | HCID 67974345 | 88.5% |
Reaction Steps
2-chloro-6-methoxy-3-(trifluoromethyl)quinoxaline (Intermediate 11, 240 mg) was suspended in MeCN (1.5 mL) with ethyl piperidine-4-carboxylate (173 mg) and TEA (205 mg) in a sealed microwave tube and heated at 150° C. with microwave for three hours. The resultant mixture was purified by silica gel column chromatography to afford 310 mg of ethyl 1-(6-methoxy-3-(trifluoromethyl)quinoxalin-2-yl)piperidine-4-carboxylate.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| Patent number | US09364481B2 |
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| Source dataset | uspto-grants-2016_06 |
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| ORD ID | ord-78610fe61bb3417ab2f6444903993b6f |
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| Source note | uspto-grants-2016_06 |
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