HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 2201479Generated: October 29, 2026
Potassium Carbonate → 3-Fluoro-4-(7-methoxyisoquinolin-3-yl)benzoic acid
https://huagongshe.com/reaction/2201479
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Potassium Carbonate | HCID 11430 | — |
| Reactant | 4-(Dihydroxyboranyl)-3-fluorobenzoic acid | HCID 23134177 | — |
| Reactant | 3-Chloro-7-methoxyisoquinoline | HCID 53425565 | — |
| Catalyst | Bis(cyclopenta-1,4-dien-1-yl(diphenyl)phosphane);dichloropalladium;iron(2+) | HCID 178418228 | — |
| Solvent | Water | HCID 962 | — |
| Solvent | Diethylene Glycol Monomethyl Ether | HCID 8134 | — |
| Product | 3-Fluoro-4-(7-methoxyisoquinolin-3-yl)benzoic acid | HCID 67974826 | 30.4% |
Reaction Steps
A mixture of 3-chloro-7-methoxyisoquinoline (Intermediate 12) (300 mg, 1.55 mmol), 4-carboxy-2-fluorophenylboronic acid (285 mg, 1.55 mmol), K2CO3 (642 mg, 4.65 mmol) and Pd(dppf)Cl2 (30 mg, 0.037 mmol) in DEGME (7 mL) and water (2 mL) was stirred under N2 atmosphere at 120° C. for 3 hours. The resulting mixture was cooled to room temperature and filtered. The filtrate was acidified with aqueous HCl (2M) until pH=6 and filtered. The solid was dried under reduced pressure to give 3-fluoro-4-(7-methoxyisoquinolin-3-yl)benzoic acid (140 mg, yield: 30%) as off-white solid.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| Patent number | US09364481B2 |
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| Source dataset | uspto-grants-2016_06 |
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| ORD ID | ord-b69979d7c2574ba68fadc96b556e3e4d |
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| Source note | uspto-grants-2016_06 |
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