HCID 117771342, compound → HCID 117771752, compound

Participants

Reaction Steps

A mixture of N-benzyl-3-(benzyloxy)-6-(2-(4-fluorophenyl)-3-(methylcarbamoyl)-6-(N-methylmethylsulfonamido)benzofuran-5-yl)picolinamide (200 mg, 0.29 mmol) and Pd/C (10 mg) in CH3OH (10 mL) was stirred at room temperature overnight under H2 atmosphere (50 psi). The mixture was filtered and the filtrate was concentrated in vacuum. The residue was purified by prep-TLC (DCM:EtOAc=5:1) to give the product of N-benzyl-6-(2-(4-fluorophenyl)-3-(methylcarbamoyl)-6-(N-methylmethylsulfonamido)benzofuran-5-yl)-3-hydroxypicolinamide (125 mg, yield: 71.8%). 1H-NMR (CDCl3, 400 MHz) δ 8.73 (br s, 1H), 7.84˜7.87 (m, 3H), 7.63 (d, J=8.4 Hz, 1H), 7.49 (s, 1H), 7.44 (d, J=8.4 Hz, 1H), 7.30˜7.36 (m, 4H), 7.26 (d, J=6.0 Hz, 1H), 7.19 (t, J=8.0 Hz, 2H), 6.39 (br s, 1H), 4.60 (d, J=4.8 Hz, 2H), 3.04 (s, 3H), 2.93 (d, J=3.2 Hz, 3H), 2.87 (s, 3H). MS (M+H)+: 603.

Provenance & Evidence