Cesium carbonate → HCID 117771380, compound

Participants

Reaction Steps

To a solution of 6-bromo-N-(4-chlorobenzyl)-3-hydroxypicolinamide (200 mg, 0.59 mmol) and Cs2CO3 (516 mg, 2.93 mmol) in DMF (5 mL) was added chloroiodomethane (382 mg, 1.17 mmol) dropwise at 100° C. for 10 minutes. The mixture was concentrated in vacuo and the residue was suspended in water. The mixture was extracted with EtOAc and the organic phase was washed with brine, dried over sodium sulfate and concentrated in vacuo to give the crude 6-bromo-3-(4-chlorobenzyl)-2H-pyrido[2,3-e][1,3]oxazin-4(3H)-one (150 mg, yield: 73%) without further purification. MS (M+H)+: 353/355.

Provenance & Evidence