Water → 6-bromo-3-(4-fluorobenzyl)-2H-pyrido[3,2-e][1,3]oxazin-4(3H)-one

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Reaction Conditions

Reaction Steps

Chloroiodomethane (897 mg, 5.1 mmol) was slowly added to a mixture of 5-bromo-N-(4-fluorobenzyl)-2-hydroxynicotinamide (1.5 g, 4.6 mmol) and Cs2CO3 (6.0 g, 18.4 mmol) in DMF (20 mL) at 100° C. The mixture was stirred at 100° C. for 2 h. Water was added and the mixture was extracted with EtOAc. After being concentrated, the residue was purified by column chromatography (PE:EtOAc=2:1) to give the product of 6-bromo-3-(4-fluorobenzyl)-2H-pyrido[3,2-e][1,3]oxazin-4(3H)-one (140 mg, yield: 9%). 1H-NMR (DMSO-d6, 400 MHz) δ 8.46 (d, J=2.4 Hz, 1H), 8.44 (d, J=2.4 Hz, 1H), 7.40 (dd, J=5.6, 8.8 Hz, 2H), 7.09 (t, J=8.8 Hz, 2H), 5.40 (s, 2H), 4.74 (s, 2H). MS (M+H)+: 337/339.

Provenance & Evidence