Triethylamine → HCID 87056047, compound

Participants

Reaction Steps

A mixture of N-(4-fluorobenzyl)-6-(2-(4-fluorophenyl)-3-(methylcarbamoyl)-6-(N-methylmethylsulfonamido)benzofuran-5-yl)-3-hydroxypicolinamide (30 mg, 0.05 mmol) and Et3N (11 mg, 0.10 mmol) in CH2Cl2 (5 mL) was stirred at RT under N2 atmosphere, and then triphosgene (18 mg, 0.06 mmol) was added portionwise. The mixture was stirred at RT for 4 h. The solvent was removed by rotary evaporator. After purified by prep-TLC (DCM:MeOH=60:1), 5-(3-(4-fluorobenzyl)-2,4-dioxo-3,4-dihydro-2H-pyrido[2,3-e][1,3]oxazin-6-yl)-2-(4-fluorophenyl)-N-methyl-6-(N-methylmethylsulfonamido)benzofuran-3-carboxamide was obtained. (15 mg, yield: 48%). 1H-NMR (CDCl3, 400 MHz) δ 7.97˜8.05 (m, 2H), 7.92 (m, 2H), 7.72 (d, J=8.4 Hz, 1H), 7.52˜7.63 (m, 3H), 7.19 (t, J=8.4 Hz, 2H), 7.01 (t, J=8.4 Hz, 2H), 6.14 (d, J=4.4 Hz, 1H), 5.20 (s, 2H), 3.24 (s, 3H), 2.98 (d, J=4.8 Hz, 3H), 2.95 (s, 3H). MS (M+H)+: 647.

Provenance & Evidence