2-Dicyclohexylphosphino-2',4',6'-triisoprophylbiphenyl → HCID 136352857, compound

HRID 2201553Notes

Reaction equation

HRID 2201553 reaction equation
[F:1][C:2]1[CH:7]=[CH:6][C:5]([C:8]2[O:9][C:10]3[CH:20]=[C:19]([N:21]([CH3:26])[S:22]([CH3:25])(=[O:24])=[O:23])[C:18](B4OC(C)(C)C(C)(C)O4)=[CH:17][C:11]=3[C:12]=2[C:13]([NH:15][CH3:16])=[O:14])=[CH:4][CH:3]=1.[F:36][C:37]1[CH:38]=[C:39]([C:43]2[NH:44][C:45](=[O:53])[C:46]3[CH:52]=[CH:51][CH:50]=[N:49][C:47]=3[N:48]=2)[CH:40]=[CH:41][CH:42]=1.CC(C1C=C(C(C)C)C(C2C=CC=CC=2P(C2CCCCC2)C2CCCCC2)=C(C(C)C)C=1)C>O1CCOCC1.O.C1C=CC(/C=C/C(/C=C/C2C=CC=CC=2)=O)=CC=1.C1C=CC(/C=C/C(/C=C/C2C=CC=CC=2)=O)=CC=1.C1C=CC(/C=C/C(/C=C/C2C=CC=CC=2)=O)=CC=1.[Pd].[Pd]>[F:1][C:2]1[CH:7]=[CH:6][C:5]([C:8]2[O:9][C:10]3[CH:20]=[C:19]([N:21]([CH3:26])[S:22]([CH3:25])(=[O:24])=[O:23])[C:18]([C:51]4[CH:50]=[N:49][C:47]5[N:48]=[C:43]([C:39]6[CH:40]=[CH:41][CH:42]=[C:37]([F:36])[CH:38]=6)[NH:44][C:45](=[O:53])[C:46]=5[CH:52]=4)=[CH:17][C:11]=3[C:12]=2[C:13]([NH:15][CH3:16])=[O:14])=[CH:4][CH:3]=1

Participants

6

Reactant 3

HCID 111557942-Dicyclohexylphosphino-2',4',6'-triisoprophylbiphenylHCID 682394022-(4-fluorophenyl)-N-methyl-6-(N-methylmethylsulfonamido)-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)benzofuran-3-carboxamideHCID 137001381HCID 137001381, compound

Product 1

HCID 136352857HCID 136352857, compoundYield 13.5%

Reagents, catalysts & solvents 2

HCID 9811564Bis(dibenzylideneacetone)palladiumSolventHCID 218864351,4-Dioxane--water (1/1)Solvent

Conditions

Temperature
80 °C

Procedure

To a mixture of 2-(4-fluorophenyl)-N-methyl-6-(N-methylmethylsulfonamido)-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)benzofuran-3-carboxamide (90 mg, 0.18 mmol), 2-(3-fluorophenyl)pyrido[2,3-d]pyrimidin-4(3H)-one (63 mg, 0.19 mmol) and K3PO4.3H2O (143 mg, 0.54 mmol) in 1,4-dioxane/H2O (3 mL/0.3 mL), Pd2(dba)3 and X-Phos (10 mg/10 mg) were added under N2 protection. After being stirred at 80° C. for 5 h, the reaction mixture was concentrated in vacuo, suspended in water and extracted with EtOAc. The organic layer was washed with brine, dried over Na2SO4 and concentrated. The residue was purified by prep-HPLC give the product of 2-(4-fluorophenyl)-5-(2-(3-fluorophenyl)-4-oxo-3,4-dihydropyrido[2,3-d]pyrimidin-6-yl)-N-methyl-6-(N-methylmethylsulfonamido)benzofuran-3-carboxamide (15 mg, yield: 13%). 1H-NMR (DMSO-d6, 400 MHz) δ 12.97 (br s, 1H), 9.03 (d, J=2.4 Hz, 1H), 8.50˜8.60 (m, 2H), 8.16 (s, 1H), 8.12 (d, J=7.6 Hz, 1H), 8.00˜8.09 (m, 3H), 7.79 (s, 1H), 7.65 (dd, J=14.0, 8.0 Hz, 1H), 7.46˜7.52 (m, 1H), 7.43 (t, J=8.8 Hz, 2H), 3.26 (s, 3H), 3.02 (s, 3H), 2.85 (d, J=4.8 Hz, 3H). MS (M+H)+: 616.

Workup

  1. additionwere added under N2 protection
  2. concentrationthe reaction mixture was concentrated in vacuo
  3. extractionextracted with EtOAc
  4. washThe organic layer was washed with brine
  5. dry with materialdried over Na2SO4
  6. concentrationconcentrated
  7. customThe residue was purified

Sources & evidence

ORD record
ord-91f9c827a6774b9180edb3800b2cc0a8
Source dataset
uspto-grants-2016_06
Patent number
US09364482B2

Reaction notes

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