2-(4-fluorophenyl)-N-methyl-6-(N-methylmethylsulfonamido)-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)benzofuran-3-carboxamide → HCID 87056045, compound

Participants

Reaction Conditions

Reaction Steps

To a solution of 6-bromo-3-(4-fluorobenzyl)-2,3-dihydropyrido[2,3-d]pyrimidin-4(1H)-one (110 mg, 0.33 mmol), 2-(4-fluorophenyl)-N-methyl-6-(N-methylmethylsulfonamido)-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)benzofuran-3-carboxamide (150 mg, 0.30 mmol) and K3PO4.3H2O (159 mg, 0.60 mmol) in dioxane/water (2 mL/0.2 mL) was added Pd(dppf)Cl2 (10 mg) under nitrogen. The mixture was heated at 100° C. for 5 h, and after being concentrated in vacuo, the residue was suspended in water. The suspension was extracted with EtOAc and the organic phase was washed with brine and dried over sodium sulfate. Finally, 5-(3-(4-fluorobenzyl)-4-oxo-1,2,3,4-tetrahydropyrido[2,3-d]pyrimidin-6-yl)-2-(4-fluorophenyl)-N-methyl-6-(N-methylmethylsulfonamido)benzofuran-3-carboxamide (80 mg, yield: 42%) was obtained by the prep-HPLC. 1H-NMR (CDCl3, 400 MHz) δ 8.27˜9.00 (m, 2H), 7.93˜7.96 (m, 2H), 7.80 (s, 1H), 7.64 (s, 1H), 7.33˜7.36 (m, 2H), 7.20 (t, J=8.8 Hz, 2H), 7.05 (t, J=8.4 Hz, 2H), 5.85 (br s, 1H), 5.26 (br s, 1H), 4.72 (s, 4H), 3.19 (s, 3H), 3.02 (d, J=4.8 Hz, 3H), 2.87 (s, 3H). MS (M+H)+: 632.

Provenance & Evidence