Ethyl orthoformate → HCID 117771578, compound

Participants

Reaction Conditions

Reaction Steps

A mixture of 3-amino-6-bromo-N-(2-fluorophenyl)picolinamide (160 mg, 0.516 mmol) in triethoxymethane (5 mL) was stirred at 130° C. for 15 h. The mixture was cooled to room temperature and extracted with ethyl acetate (10 mL*3), the combined organic layers were washed with brine, dried over anhydrous sodium sulfate, filtered and concentrated to afford 6-bromo-3-(2-fluorophenyl)pyrido[3,2-d]pyrimidin-4(3H)-one (75 mg, yield: 45%), which was used for the next step without further purification. MS (M+H)+:320/322

Provenance & Evidence