3-Fluoroaniline → HCID 117771083, compound

Participants

Reaction Steps

3-amino-6-bromopyrazine-2-carboxylic acid (500 mg, 2.29 mmol), HOBT (464 mg, 3.44 mmol) and EDCI (660 mg, 3.44 mmol) were dissolved in dry DMF (20 mL), and the resulting solution was stirred for 6 hours. Then 3-fluoroaniline (305 mg, 2.75 mmol) and Et3N (0.43 mL) was added to the mixture. After being stirred overnight, the mixture was diluted with water and extracted with EtOAc. The combined organic phases were washed with brine, dried over Na2SO4, filtered and evaporated. The crude product was purified by prep-TLC (PE:EtOAc=6:1) to give the pure product of 3-amino-6-bromo-N-(3-fluorophenyl)pyrazine-2-carboxamide (500 mg, yield: 68%). 1H-NMR (CDCl3, 400 MHz) δ 9.44 (s, 1H), 8.22 (s, 1H), 7.59 (d, J=11.2 Hz, 1H), 7.24˜7.27 (m, 2H), 6.79˜6.82 (m, 1H), 3.21 (s, 2H). MS (M+H)+: 311/313.

Provenance & Evidence