Acetic Anhydride → HCID 117771835, compound

Participants

Reaction Conditions

Reaction Steps

To a solution of 3-amino-6-bromo-N-(3-fluorophenyl)pyrazine-2-carboxamide (100 mg, 0.29 mmol) in triethoxymethane (5 mL) was added Ac2O (1 mL). The mixture was stirred at 130° C. for 1 h and 90° C. for 3 h. After being cooled and extracted with EtOAc, the combined organic phases were washed with brine, dried over Na2SO4, filtered and evaporated. The crude product was purified by prep-TLC (PE:EtOAc=1:1) to give the pure product of 6-bromo-3-(3-fluorophenyl)pteridin-4(3H)-one (60 mg, yield: 60%). 1H-NMR (CDCl3, 400 MHz) δ 8.98 (s, 1H), 8.35 (s, 1H), 7.49˜7.55 (m, 1H), 7.15˜7.24 (m, 3H). MS (M+H)+: 321/323.

Provenance & Evidence