2-Dicyclohexylphosphino-2',4',6'-triisoprophylbiphenyl → 5-(6-(4-fluorobenzyl)-7-oxo-6,7-dihydro-5H-pyrrolo[3,4-b]pyridin-2-yl)-2-(4-fluorophenyl)-N-methyl-6-(N-methylmethylsulfonamido)benzofuran-3-carboxamide

HRID 2201581Notes

Reaction equation

HRID 2201581 reaction equation
Cl[C:2]1[N:7]=[C:6]2[C:8](=[O:19])[N:9]([CH2:11][C:12]3[CH:17]=[CH:16][C:15]([F:18])=[CH:14][CH:13]=3)[CH2:10][C:5]2=[CH:4][CH:3]=1.[F:20][C:21]1[CH:26]=[CH:25][C:24]([C:27]2[O:28][C:29]3[CH:39]=[C:38]([N:40]([CH3:45])[S:41]([CH3:44])(=[O:43])=[O:42])[C:37](B4OC(C)(C)C(C)(C)O4)=[CH:36][C:30]=3[C:31]=2[C:32]([NH:34][CH3:35])=[O:33])=[CH:23][CH:22]=1.CC(C1C=C(C(C)C)C(C2C=CC=CC=2P(C2CCCCC2)C2CCCCC2)=C(C(C)C)C=1)C>O1CCOCC1.O.C1C=CC(/C=C/C(/C=C/C2C=CC=CC=2)=O)=CC=1.C1C=CC(/C=C/C(/C=C/C2C=CC=CC=2)=O)=CC=1.C1C=CC(/C=C/C(/C=C/C2C=CC=CC=2)=O)=CC=1.[Pd].[Pd]>[F:18][C:15]1[CH:16]=[CH:17][C:12]([CH2:11][N:9]2[CH2:10][C:5]3[C:6](=[N:7][C:2]([C:37]4[C:38]([N:40]([CH3:45])[S:41]([CH3:44])(=[O:43])=[O:42])=[CH:39][C:29]5[O:28][C:27]([C:24]6[CH:25]=[CH:26][C:21]([F:20])=[CH:22][CH:23]=6)=[C:31]([C:32]([NH:34][CH3:35])=[O:33])[C:30]=5[CH:36]=4)=[CH:3][CH:4]=3)[C:8]2=[O:19])=[CH:13][CH:14]=1

Participants

6

Reactant 3

HCID 111557942-Dicyclohexylphosphino-2',4',6'-triisoprophylbiphenylHCID 682394022-(4-fluorophenyl)-N-methyl-6-(N-methylmethylsulfonamido)-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)benzofuran-3-carboxamideHCID 1177716762-chloro-6-(4-fluorobenzyl)-5H-pyrrolo[3,4-b]pyridin-7(6H)-one

Product 1

HCID 870549835-(6-(4-fluorobenzyl)-7-oxo-6,7-dihydro-5H-pyrrolo[3,4-b]pyridin-2-yl)-2-(4-fluorophenyl)-N-methyl-6-(N-methylmethylsulfonamido)benzofuran-3-carboxamideYield 27.2%

Reagents, catalysts & solvents 2

HCID 9811564Bis(dibenzylideneacetone)palladiumCatalystHCID 218864351,4-Dioxane--water (1/1)Solvent

Procedure

A solution of 2-chloro-6-(4-fluorobenzyl)-5H-pyrrolo[3,4-b]pyridin-7(6H)-one (70 mg, 0.25 mmol), 2-(4-fluorophenyl)-N-methyl-6-(N-methylmethylsulfonamido)-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)benzofuran-3-carboxamide (152 mg, 0.30 mmol), K3PO4.3H2O (200 mg, 0.76 mmol), Pd2(dba)3 (23 mg, 0.03 mmol) and X-Phos (23 mg, 0.06 mmol) in dioxane/H2O (2 mL/0.5 mL) was stirred at 110° C. for 1 hour. After the reaction, the mixture was filtered and the filtrate was diluted with water (20 mL) and extracted with EtOAc (20 mL*3). The organic layer was washed with brine (10 mL*3), dried over Na2SO4 and concentrated. The residue was purified by prep-HPLC to afford the product of 5-(6-(4-fluorobenzyl)-7-oxo-6,7-dihydro-5H-pyrrolo[3,4-b]pyridin-2-yl)-2-(4-fluorophenyl)-N-methyl-6-(N-methylmethylsulfonamido)benzofuran-3-carboxamide (42 mg, yield: 27%). 1H-NMR (CDCl3, 400 MHz) δ 7.97˜8.02 (m, 3H), 7.82˜7.88 (m, 2H), 7.64 (s, 1H), 7.33˜7.36 (m, 2H), 7.22 (t, J=8.8 Hz, 2H) 7.18 (t, J=8.4 Hz, 2H), 6.08 (br s, 1H), 4.86 (s, 2H), 4.34 (s, 2H), 3.16 (s, 3H), 3.01 (d, J=4.8 Hz, 3H), 2.99 (s, 3H). MS (M+H)+: 617.

Workup

  1. customAfter the reaction
  2. filtrationthe mixture was filtered
  3. additionthe filtrate was diluted with water (20 mL)
  4. extractionextracted with EtOAc (20 mL*3)
  5. washThe organic layer was washed with brine (10 mL*3)
  6. dry with materialdried over Na2SO4
  7. concentrationconcentrated
  8. customThe residue was purified by prep-HPLC

Sources & evidence

ORD record
ord-f9d949cc872d45efb9a7c2be84fa5645
Source dataset
uspto-grants-2016_06
Patent number
US09364482B2

Reaction notes

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