4-Fluorobenzyl bromide → HCID 117771288, compound

Participants

Reaction Steps

To a solution of 7-bromo-3,4-dihydroisoquinolin-1(2H)-one (150 mg, 0.66 mmol) and 1-(bromomethyl)-4-fluorobenzene (151 mg, 0.80 mmol) in 1,4-dioxane (5 ml) was added potassium t-butoxide (112 mg, 1.00 mmol). The resulting mixture was stirred at RT overnight. Solids were removed by filtration. Then the mixture was concentrated in vacuo to give 7-bromo-2-(4-fluorobenzyl)-3,4-dihydroisoquinolin-1(2H)-one (222 mg, yield: 100%). MS (M+H)+: 335.

Provenance & Evidence