4-Fluorobenzyl bromide → HCID 117771288, compound

Participants

Reaction Steps

To a solution of 7-bromoisoquinolin-1(2H)-one (300 mg, 1.34 mmol) and 1-(bromomethyl)-4-fluorobenzene (380 mg, 2.01 mmol) in THF (8 ml) was added potassium t-butoxide (300 mg, 2.68 mmol) and tetrabutylammonium iodide (50 mg, 0.13 mmol). The resulting mixture was stirred at RT for 3 h. The solid was removed by filtration, then concentrated in vacuo. The resulting residue was purified using column chromatography (eluted with 0-30% EtOAc/DCM) to provide 7-bromo-2-(4-fluorobenzyl)-3,4-dihydroisoquinolin-1(2H)-one (410 mg, yield: 92%) (M+H)+: 333.

Provenance & Evidence