indium(III)chloride → HCID 178515844, compound

HRID 220162Notes

Reaction equation

HRID 220162 reaction equation
[Cl-].[In+3].[Cl-].[Cl-].O1[C:9]2([CH2:14][CH2:13][CH:12]([C:15]3[CH:20]=[CH:19][C:18]([C:21]4[CH:25]=[C:24]([O:26][CH2:27][C:28]5[CH:33]=[CH:32][CH:31]=[CH:30][C:29]=5[O:34][C:35]([F:38])([F:37])[F:36])[NH:23][N:22]=4)=[CH:17][N:16]=3)[CH2:11][CH2:10]2)[O:8]CC1>CO.O>[F:38][C:35]([F:36])([F:37])[O:34][C:29]1[CH:30]=[CH:31][CH:32]=[CH:33][C:28]=1[CH2:27][O:26][C:24]1[NH:23][N:22]=[C:21]([C:18]2[CH:19]=[CH:20][C:15]([CH:12]3[CH2:13][CH2:14][C:9](=[O:8])[CH2:10][CH2:11]3)=[N:16][CH:17]=2)[CH:25]=1

Participants

5

Reactant 2

HCID 159675indium(III)chlorideHCID 178506374HCID 178506374, compound

Product 1

HCID 178515844HCID 178515844, compound

Reagents, catalysts & solvents 2

HCID 887MethanolSolvent2×HCID 962WaterSolvent

Procedure

Indium chloride (0.11 g, 0.536 mmol) was added to a solution of Example 93E (0.255 g, 0.536 mmol) in methanol (3 ml) and water (3 mL). The resulting solution was heated (85° C.) for 5 hours before the methanol was evaporated. The residue was partitioned with ethyl acetate and water, and the organic phase was washed with brine, dried (magnesium sulfate), filtered, and concentrated. The crude product was used in the following step without further purification.

Workup

  1. customwas evaporated
  2. customThe residue was partitioned with ethyl acetate and water
  3. washthe organic phase was washed with brine
  4. dry with materialdried (magnesium sulfate)
  5. filtrationfiltered
  6. concentrationconcentrated
  7. customThe crude product was used in the following step without further purification

Sources & evidence

ORD record
ord-07b13aceba11400cb834491642881eec
Source dataset
uspto-grants-2012_06
Patent number
US08202878B2

Reaction notes

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