Oxygen → HCID 46843534, compound

HRID 2201634Notes

Reaction equation

HRID 2201634 reaction equation
O=O.[F:3][C:4]1[CH:5]=[C:6]([S:10][C:11]2[CH:12]=[C:13]3[C:18](=[CH:19][CH:20]=2)[C:17]([C:21]([NH2:23])=[O:22])=[CH:16][CH2:15][CH2:14]3)[CH:7]=[CH:8][CH:9]=1.[H][H]>CO>[F:3][C:4]1[CH:5]=[C:6]([S:10][C:11]2[CH:12]=[C:13]3[C:18](=[CH:19][CH:20]=2)[C@H:17]([C:21]([NH2:23])=[O:22])[CH2:16][CH2:15][CH2:14]3)[CH:7]=[CH:8][CH:9]=1

Participants

5

Reactant 3

HCID 977OxygenHCID 59378877HCID 59378877, compoundHCID 178418361HCID 178418361, compound

Product 1

HCID 46843534HCID 46843534, compoundYield 92.2%

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

In a glove box (O2 content≦2 ppm) a 35 ml autoclave equipped with a glass insert and a magnetic stirring bar was charged with 250 mg (0.835 mmol) of 6-(3-Fluoro-phenylsulfanyl)-3,4-dihydro-naphthalene-1-carboxylic acid amide, 4.03 mg (0.00418 mmol) of [Ru(trifluoroacetate)2((S)-pTol-MeOBIPHEP)] (S/C 200) and 3 ml of methanol. The asymmetric hydrogenation was run for 24 h at 40° C. under 40 bar of hydrogen. After cooling to room temperature the pressure was released from the autoclave, the methanol solution was evaporated in vacuo. The residue was dissolved in 4 ml of dichloromethane and filtered through a silicagel pad, which was washed with a total of 6 ml of dichloromethane. Evaporation of the filtrate and drying (50° C./10 mbar/2 hours) afforded 232 mg of (R)-6-(3-Fluoro-phenylsulfanyl)-1,2,3,4-tetrahydro-naphthalene-1-carboxylic acid amide as a light yellow solid with an enantiomeric ratio of 99:1. The conversion was >=99.9%.

Workup

  1. customthe methanol solution was evaporated in vacuo
  2. dissolutionThe residue was dissolved in 4 ml of dichloromethane
  3. filtrationfiltered through a silicagel pad, which
  4. washwas washed with a total of 6 ml of dichloromethane
  5. customEvaporation of the filtrate
  6. customdrying (50° C./10 mbar/2 hours)

Sources & evidence

ORD record
ord-0d89dd90060142e8ac36249a03e0142b
Source dataset
uspto-grants-2016_06
Patent number
US09365494B2

Reaction notes

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