Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Sodium Hydroxide | HCID 14798 | — |
| Reactant | Hydrazine hydrate (1:1) | HCID 24654 | — |
| Reactant | HCID 71243327 | HCID 71243327 | — |
| Solvent | Triethylene Glycol | HCID 8172 | — |
| Product | HCID 65009295 | HCID 65009295 | 73.1% |
Reaction Steps
Compound 4-5 (2 g, 7.32 mmol) and hydrazine monohydrate (0.828 g, 16.5 mmol) and NaOH (0.585 g, 14.63 mmol) were added to triethylene glycol (20 mL) and heated under reflux for 1 hour. Then remove the condenser, heated to 200° C. in an oil bath and maintained for 3 hours, and after cooling purified by column chromatography to give Compound 4-6 (0.67 g, 73% yield).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| Patent number | US09365499B2 |
|---|
| Source dataset | uspto-grants-2016_06 |
|---|
| ORD ID | ord-ced3fcf5ce8a46f9a5fef8497faa73c4 |
|---|
| Source note | uspto-grants-2016_06 |
|---|
