Hydrogen Bromide → HCID 67128628, compound

Participants

Reaction Steps

Compound 3 (1.94 g, 0.005 mol) was stirred in 48% w/v hydrobromic acid in acetic acid (11 mL) for 1 h. Diethylether was added till a cream precipitate appeared and the ethereal solution decanted. The resulting white sticky solid was suspended in dichloromethane (100 mL) and 1 M aqueous sodium hydroxide (20 mL). The aqueous layer was extracted with dichloromethane (1×50 mL) and the combined organic layers were washed with saturated brine (1×50 mL), dried (MgSO4) and concentrated in vacuo to give 4 as a pale yellow oil (975 mg, 82%).

Provenance & Evidence