HCID 90388409, compound → HCID 90388581, compound

Participants

Reaction Steps

To a solution of compound 8 (180 mg, 0.6 mmol) in EtOAc (40 mL) was added Pd/C (100 mg) and hydrogenation was carried out under 7 atm H2 at room temperature for 3 h. The reaction was filtered through Celite® 545 which was washed with EtOAc (100 mL). Solvents were removed and the residue was purified by flash column chromatography (silica gel eluted with 10% EtOAc in hexanes) to afford compound 9 (172 mg, 94%): 1H NMR (CDCl3) δ 4.58 (s, 2H), 3.82-3.79 (m, 1H), 3.29 (s, 3H), 0.84 (s, 3H); 13C NMR (CDCl3) δ 121.4, 94.5, 71.8, 54.9, 48.4, 47.9, 46.7, 44.9, 44.4, 39.7, 38.1, 37.9, 36.6, 33.8, 33.7, 30.0, 28.3, 26.3, 26.2, 23.7, 14.2.

Provenance & Evidence