HCID 90388545, compound → HCID 90388260, compound

Participants

Reaction Steps

To a solution compound 12 (150 mg, 0.54 mmol) in pyridine (30 mL) was added Pd/C (50 mg) at room temperature. A hydrogenation was carried out under 7 atm H2 for 2 h at room temperature. The reaction was filtered through Celite® 545 which was washed with EtOAc (100 mL). Solvents were removed under reduced pressure and 13C NMR of the crude product (145 mg) showed the 4aS to 4aR diastereomer ratio to be 2:1: 1H NMR (CDCl3) δ 0.84 (s, 3H); 13C NMR (CDCl3) 4aS diastereomer δ 220.4, 212.2, 47.8, 45.6, 42.7, 39.9, 38.9, 38.6, 38.2, 38.1, 36.3, 35.4, 30.7, 28.5, 28.4, 27.1, 23.9, 13.5.

Provenance & Evidence