Nitrogen → HCID 71003969, compound

Participants

Reaction Steps

To a stirred and cold (−5° C.-1-10° C.) solution of tert-butyl 3-benzyl-5-methoxy-1-oxoisoindoline-2-carboxylate (0.92 g, 2.59 mmol) in dichloromethane (9 mL) was added BBr3 (7.8 mL, 7.78 mmol) dropwise under N2. This was stirred at −5° C. for 3 hours, then room temperature for overnight. TLC showed complete conversion. The reaction mixture was poured into ice-water, extracted 3× with dichloromethane. The combined organic layer was washed 1× with water, 1× with saturated NaHCO3, 1× with saturated NaCl solution, dried over Na2SO4, concentrated down to a light yellow solid (620 mg, 100%).

Provenance & Evidence