tert-Butyl N-(2-bromoethyl)carbamate → HCID 71003970, compound

Participants

Reaction Conditions

Reaction Steps

A mixture of 3-benzyl-5-hydroxyisoindolin-1-one (360 mg, 1.51 mmol), CsCO3 (980 mg, 3.01 mmol) and tert-butyl 2-bromoethylcarbamate (506 mg, 2.26 mmol) in 4 mL of acetonitrile was heated up to 80° C. for 4 hours, TLC showed complete conversion. The solvent was evaporated and the residue was dissolved in ethyl acetate, then water was added, this was separated. The organic phase was dried on Na2SO4 and the solvent was evaporated. The residue was purified by flash-chromatography on silica gel with 100% ethyl acetate, 426 mg (1.11 mmol, 74%) of the product was obtained.

Provenance & Evidence