Triethylamine → HCID 86692163, compound

Participants

Reaction Steps

To a solution of nonafluorobutanesulfonyl fluoride (712 mg, 2.36 mmol) and NEt3 (0.49 mL, 3.54 mmol) in 3 mL of dichloromethane was added 3-benzyl-5-hydroxyisoindolin-1-one (example 1.4, 282 mg, 1.18 mmol) in 2 mL of dichloromethane slowly. This reaction mixture was stirred at room temperature for overnight. TLC showed complete conversion, the solvent was evaporated. The residue was purified by flash-chromatography on silica gel with 30-80% ethyl acetate in hexane, 474 mg (77%) of the product was obtained.

Provenance & Evidence