HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 2201774Generated: October 29, 2026
Acetic Anhydride → N-(4-methyl-5-nitropyridin-2-yl)acetamide
https://huagongshe.com/reaction/2201774
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Acetic Anhydride | HCID 7918 | — |
| Reactant | 2-Amino-4-methyl-5-nitropyridine | HCID 243165 | — |
| Product | N-(4-methyl-5-nitropyridin-2-yl)acetamide | HCID 13567013 | 87% |
Reaction Steps
A mixture of 4-methyl-5-nitropyridin-2-amine (5 g, 32 mmol) and acetic anhydride (20 mL) was heated at 90° C. for 4 hours. After cooling the solvent was evaporated under vacuum. The concentrated mass was dissolved in toluene and evaporated under vacuum. The resulting solid was triturated with diethyl ether and filtered to afford N-(4-methyl-5-nitropyridin-2-yl)acetamide (5.5 g, 87%).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| Patent number | US09364466B2 |
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| Source dataset | uspto-grants-2016_06 |
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| ORD ID | ord-252a2c3610bf42a4a52472a7b9e5b9e5 |
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| Source note | uspto-grants-2016_06 |
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