HuagongsheHuagongshe Chemistry Print Report · For research reference only
Thionyl Chloride → 4-Cyano-2,6-difluorobenzoyl chloride
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Thionyl Chloride | HCID 24386 | — |
| Reactant | 4-Cyano-2,6-difluorobenzoic acid | HCID 44557933 | — |
| Product | 4-Cyano-2,6-difluorobenzoyl chloride | HCID 86720625 | 91.18% |
Reaction Steps
A mixture of 4-cyano-2,6-difluorobenzoic acid (0.3 gm, 0.5 mmol) and thionyl chloride (5 mL) were refluxed for about 3 hours. The reaction mixture was cooled to ambient temperature, and concentrated under vacuum at 50° C. to afford 4-cyano-2,6-difluorobenzoyl chloride (0.3 gm, 91.18%).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US09364466B2 |
| Source dataset | uspto-grants-2016_06 |
| ORD ID | ord-88c3efda7e554ab1ba6cd536d247ff24 |
| Source note | uspto-grants-2016_06 |