Acetyl chloride → N-(1H-pyrrolo[3,2-c]pyridin-4-yl)acetamide

HRID 2201797Notes

Reaction equation

[NH2:1][C:2]1[C:7]2[CH:8]=[CH:9][N:10](C(OCC3C=CC=CC=3)=O)[C:6]=2[CH:5]=[CH:4][N:3]=1.[C:21](Cl)(=[O:23])[CH3:22]>>[NH:10]1[C:6]2[CH:5]=[CH:4][N:3]=[C:2]([NH:1][C:21](=[O:23])[CH3:22])[C:7]=2[CH:8]=[CH:9]1

Participants

Reactant 2

HCID 6367Acetyl chloride

HCID 71061834benzyl 4-amino-1H-pyrrolo[3,2-c]pyridine-1-carboxylate

Product 1

HCID 86720630N-(1H-pyrrolo[3,2-c]pyridin-4-yl)acetamide

Procedure

N-(1H-pyrrolo[3,2-c]pyridin-4-yl)acetamide (Intermediate 25) was prepared from benzyl 4-amino-1H-pyrrolo[3,2-c]pyridine-1-carboxylate in an analogous manner using acetyl chloride.

Sources & evidence

ORD record: ord-ce4d8548406f45e19942faf4f0b58831
Source dataset: uspto-grants-2016_06
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US09364466B2

Reaction notes

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