HuagongsheHuagongshe Chemistry Print Report · For research reference only
Water → 2-(4-Bromo-phenyl)-3-(1-methyl-piperidin-4-yl)-propionic acid
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Water | HCID 962 | — |
| Reactant | Sulfuric Acid | HCID 1118 | — |
| Reactant | Sodium Carbonate | HCID 10340 | — |
| Reactant | 2-(4-Bromo-phenyl)-3-(1-methyl-piperidin-4-yl)-propionitrile | HCID 59238306 | — |
| Solvent | Methanol | HCID 887 | — |
| Product | 2-(4-Bromo-phenyl)-3-(1-methyl-piperidin-4-yl)-propionic acid | HCID 59238328 | — |
Reaction Steps
The oily residue of 2-(4-bromo-phenyl)-3-(1-methyl-piperidin-4-yl)-propionitrile was hydrolyzed by refluxing for 2 h with 4 mL of concentrated H2SO4 and water (38:28). The mixture was neutralized with Na2CO3, then MeOH (20 mL) was added. The solid was filtered and washed with MeOH (3×10 mL). The combined methanol solution was evaporated to give an oil. MS: calc'd 326 (MH+), exp 326 (MH+).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08202866B2 |
| Source dataset | uspto-grants-2012_06 |
| ORD ID | ord-6b9b418d41204654b2aa2995156f50aa |
| Source note | uspto-grants-2012_06 |