反应详情

To the solution of 2-(4-bromo-phenyl)-3-(1-methyl-piperidin-4-yl)-propionic acid in MeOH (60 mL), SOCl2 (2 mL) was added at 0 degrees Celsius, then the mixture refluxed for 5 h. After cooling, the solution was evaporated to dryness under reduced pressure, then EtOAc was added, the organic layer was washed with aq. NaHCO3, dried with MgSO4, and evaporated to give an oil. MS: calc'd 340 (MH+), exp 340 (MH+).

1. temperaturethe mixture refluxed for 5 h
2. temperatureAfter cooling
3. customthe solution was evaporated to dryness under reduced pressure
4. additionEtOAc was added
5. washthe organic layer was washed with aq. NaHCO3
6. dry with materialdried with MgSO4
7. customevaporated
8. customto give an oil