N-(1H-Pyrrolo[2,3-c]pyridin-7-yl)acetamide → 4-{[7-(Acetylamino)-1H-pyrrolo[2,3-c]pyridin-3-yl]carbonyl}-3,5-dichloro-N-propylbenzamide
Reaction equation
[NH:1]1[C:5]2=[C:6]([NH:10][C:11](=[O:13])[CH3:12])[N:7]=[CH:8][CH:9]=[C:4]2[CH:3]=[CH:2]1.[Cl:14][C:15]1[CH:20]=[C:19]([C:21](=[O:26])[NH:22][CH2:23][CH2:24][CH3:25])[CH:18]=[C:17]([Cl:27])[C:16]=1[C:28](Cl)=[O:29]>>[C:11]([NH:10][C:6]1[N:7]=[CH:8][CH:9]=[C:4]2[C:3]([C:28]([C:16]3[C:17]([Cl:27])=[CH:18][C:19]([C:21]([NH:22][CH2:23][CH2:24][CH3:25])=[O:26])=[CH:20][C:15]=3[Cl:14])=[O:29])=[CH:2][NH:1][C:5]=12)(=[O:13])[CH3:12]Participants
3
Procedure
4-{[7-(Acetylamino)-1H-pyrrolo[2,3-c]pyridin-3-yl]carbonyl}-3,5-dichloro-N-propylbenzamide was prepared from N-(1H-pyrrolo[2,3-c]pyridin-7-yl)acetamide and 2,6-dichloro-4-(1-propylcarbamoyl)benzene carbonyl chloride (Compound No. 15).
Sources & evidence
- ORD record
- ord-66ecc71f556942f3ba6961d7c2f61962
- Source dataset
- uspto-grants-2016_06
- Patent number
- US09364466B2
Reaction notes
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