N-(1H-Pyrrolo[2,3-c]pyridin-7-yl)acetamide → 4-{[7-(Acetylamino)-1H-pyrrolo[2,3-c]pyridin-3-yl]carbonyl}-3,5-dichloro-N-(2-methoxyethyl)benzamide
Reaction equation
[NH:1]1[C:5]2=[C:6]([NH:10][C:11](=[O:13])[CH3:12])[N:7]=[CH:8][CH:9]=[C:4]2[CH:3]=[CH:2]1.[Cl:14][C:15]1[CH:20]=[C:19]([C:21](=[O:27])[NH:22][CH2:23][CH2:24][O:25][CH3:26])[CH:18]=[C:17]([Cl:28])[C:16]=1[C:29](Cl)=[O:30]>>[C:11]([NH:10][C:6]1[N:7]=[CH:8][CH:9]=[C:4]2[C:3]([C:29]([C:16]3[C:17]([Cl:28])=[CH:18][C:19]([C:21]([NH:22][CH2:23][CH2:24][O:25][CH3:26])=[O:27])=[CH:20][C:15]=3[Cl:14])=[O:30])=[CH:2][NH:1][C:5]=12)(=[O:13])[CH3:12]Participants
3
Procedure
4-{[7-(Acetylamino)-1H-pyrrolo[2,3-c]pyridin-3-yl]carbonyl}-3,5-dichloro-N-(2-methoxyethyl)benzamide was prepared analogously using N-(1H-pyrrolo[2,3-c]pyridin-7-yl)acetamide and 2,6-dichloro-4-(2-methoxyethylcarbamoyl)benzene carbonyl chloride (Compound No. 17).
Sources & evidence
- ORD record
- ord-be107436df8c44d1b5c1208b6e81924e
- Source dataset
- uspto-grants-2016_06
- Patent number
- US09364466B2
Reaction notes
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