2-Chloro-6-fluorobenzoyl chloride → N-[3-(2-Chloro-6-fluorobenzoyl)-1H-pyrrolo[2,3-c]pyridin-5-yl]cyclopropanecarboxamide

HRID 2201828Notes

Reaction equation

HRID 2201828 reaction equation
[NH:1]1[C:5]2=[CH:6][N:7]=[C:8]([NH:10][C:11]([CH:13]3[CH2:15][CH2:14]3)=[O:12])[CH:9]=[C:4]2[CH:3]=[CH:2]1.[Cl:16][C:17]1[CH:25]=[CH:24][CH:23]=[C:22]([F:26])[C:18]=1[C:19](Cl)=[O:20]>>[Cl:16][C:17]1[CH:25]=[CH:24][CH:23]=[C:22]([F:26])[C:18]=1[C:19]([C:3]1[C:4]2[C:5](=[CH:6][N:7]=[C:8]([NH:10][C:11]([CH:13]3[CH2:14][CH2:15]3)=[O:12])[CH:9]=2)[NH:1][CH:2]=1)=[O:20]

Participants

3

Reactant 2

HCID 27365472-Chloro-6-fluorobenzoyl chlorideHCID 86720641N-(1H-Pyrrolo[2,3-c]pyridin-5-yl)cyclopropanecarboxamide

Product 1

HCID 86720642N-[3-(2-Chloro-6-fluorobenzoyl)-1H-pyrrolo[2,3-c]pyridin-5-yl]cyclopropanecarboxamide

Procedure

N-[3-(2-Chloro-6-fluorobenzoyl)-1H-pyrrolo[2,3-c]pyridin-5-yl]cyclopropanecarboxamide was prepared using N-(1H-pyrrolo[2,3-c]pyridin-5-yl)cyclopropane carboxamide and 2-chloro-6-fluoro benzoyl chloride (Compound No. 19).

Sources & evidence

ORD record
ord-7896559195b64be5a7d39acbd7a59cf7
Source dataset
uspto-grants-2016_06
Patent number
US09364466B2

Reaction notes

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