2,4,6-Trichlorobenzoyl chloride → N-[3-(2,4,6-trichlorobenzoyl)-1H-pyrrolo[2,3-c]pyridin-7-yl]cyclopropanecarboxamide

HRID 2201832Notes

Reaction equation

HRID 2201832 reaction equation
[NH:1]1[C:5]2=[CH:6][N:7]=[C:8]([NH:10][C:11]([CH:13]3[CH2:15][CH2:14]3)=[O:12])[CH:9]=[C:4]2[CH:3]=[CH:2]1.[Cl:16][C:17]1[CH:25]=[C:24]([Cl:26])[CH:23]=[C:22]([Cl:27])[C:18]=1[C:19](Cl)=[O:20]>>[Cl:16][C:17]1[CH:25]=[C:24]([Cl:26])[CH:23]=[C:22]([Cl:27])[C:18]=1[C:19]([C:3]1[C:4]2[C:9](=[C:8]([NH:10][C:11]([CH:13]3[CH2:15][CH2:14]3)=[O:12])[N:7]=[CH:6][CH:5]=2)[NH:1][CH:2]=1)=[O:20]

Participants

3

Reactant 2

HCID 27337032,4,6-Trichlorobenzoyl chlorideHCID 86720641N-(1H-Pyrrolo[2,3-c]pyridin-5-yl)cyclopropanecarboxamide

Product 1

HCID 71618428N-[3-(2,4,6-trichlorobenzoyl)-1H-pyrrolo[2,3-c]pyridin-7-yl]cyclopropanecarboxamide

Procedure

N-[3-(2,4,6-Trichlorobenzoyl)-1H-pyrrolo[2,3-c]pyridin-7-yl]cyclopropanecarboxamide (Compound No. 45) was prepared using N-(1H-pyrrolo[2,3-c]pyridin-5-yl)cyclopropane carboxamide and 2,4,6-trichlorobenzoyl chloride.

Sources & evidence

ORD record
ord-d475650bfd084a8ab5c16b5032c7eb00
Source dataset
uspto-grants-2016_06
Patent number
US09364466B2

Reaction notes

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