2,6-Dichloro-4-[(propan-2-yl)carbamoyl]benzoic acid → 3,5-Dichloro-4-({4-[(cyclopropylcarbonyl)amino]-1H-pyrrolo[3,2-c]pyridin-1-yl}carbonyl)-N-(propan-2-yl)benzamide

HRID 2201858Notes

Reaction equation

HRID 2201858 reaction equation
[NH:1]1[C:9]2[CH:8]=[CH:7][N:6]=[C:5]([NH:10][C:11]([CH:13]3[CH2:15][CH2:14]3)=[O:12])[C:4]=2[CH:3]=[CH:2]1.[Cl:16][C:17]1[CH:25]=[C:24]([C:26](=[O:31])[NH:27][CH:28]([CH3:30])[CH3:29])[CH:23]=[C:22]([Cl:32])[C:18]=1[C:19](O)=[O:20]>>[Cl:16][C:17]1[CH:25]=[C:24]([CH:23]=[C:22]([Cl:32])[C:18]=1[C:19]([N:1]1[C:9]2[CH:8]=[CH:7][N:6]=[C:5]([NH:10][C:11]([CH:13]3[CH2:14][CH2:15]3)=[O:12])[C:4]=2[CH:3]=[CH:2]1)=[O:20])[C:26]([NH:27][CH:28]([CH3:30])[CH3:29])=[O:31]

Participants

3

Reactant 2

HCID 710613072,6-Dichloro-4-[(propan-2-yl)carbamoyl]benzoic acidHCID 86720627N-(1H-pyrrolo[3,2-c]pyridin-4-yl)cyclopropanecarboxamide

Product 1

HCID 716187573,5-Dichloro-4-({4-[(cyclopropylcarbonyl)amino]-1H-pyrrolo[3,2-c]pyridin-1-yl}carbonyl)-N-(propan-2-yl)benzamide

Procedure

3,5-Dichloro-4-({4-[(cyclopropylcarbonyl)amino]-1H-pyrrolo[3,2-c]pyridin-1-yl}carbonyl)-N-(propan-2-yl)benzamide (Compound No. 106) was prepared using N-(1H-pyrrolo[3,2-c]pyridin-4-yl)cyclopropane carboxamide and 2,6-dichloro-4-[(propan-2-yl)carbamoyl]benzoic acid.

Sources & evidence

ORD record
ord-0a35dd3f7e41499f800030e6a32ea5d9
Source dataset
uspto-grants-2016_06
Patent number
US09364466B2

Reaction notes

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