Ethyl Acetate → HCID 71061894, compound

Participants

Reaction Conditions

Reaction Steps

A mixture of N-[1-(4-bromo-2,6-dichlorobenzoyl)-1H-pyrrolo[3,2-c]pyridin-4-yl]-N-(cyclopropylcarbonyl)cyclopropanecarboxamide (40 mg, 0.11 mmol), dppf (10 mg, 0.018 mmol), copper cyanide (41 mg, 0.45 mmol) and cesium carbonate (110 mg, 0.33 mmol) in 1,4-dioxane (2 mL) was heated in a sealed vial at 90° C. for 4 hours. Ethyl acetate was added and washed with saturated aqueous sodium hydrogen carbonate solution, dried over anhydrous sodium sulphate and concentrated to get the crude residue which was purified by silica gel column chromatography to afford N-(cyclopropylcarbonyl)-N-[1-(2,6-dichloro-4-cyanobenzoyl)-1H-pyrrolo[3,2-c]pyridin-4-yl]cyclopropanecarboxamide and N-[1-(2,6-dichloro-4-cyanobenzoyl)-1H-pyrrolo[3,2-c]pyridin-4-yl]cyclopropanecarboxamide.

Provenance & Evidence