Ethanol → HCID 71061298, compound

Participants

Reaction Conditions

Reaction Steps

A mixture of methyl {5-iodo-2-[(2,4,4-trimethylpentan-2-yl)amino]pyridin-4-yl}carbamate (1.3 g, 3.2 mmol), potassium hydroxide (898 mg, 16 mmol), ethanol (10 mL) and water (10 mL) was heated at 80° C. for 2 hours. Ethanol was removed under vacuum, and the residue was stirred in water. The precipitated solid was filtered under vacuum and dried to yield 900 mg (81%) of 5-iodo-N2-(2,4,4-trimethylpentan-2-yl)pyridine-2,4-diamine.

Provenance & Evidence