2,6-Dichlorobenzoyl chloride → N-[1-(2,6-dichlorobenzoyl)-1H-pyrrolo[3,2-c]pyridin-6-yl]-N-(2,4,4-trimethylpentan-2-yl)cyclopropanecarboxamide

HRID 2201877Notes

Reaction equation

HRID 2201877 reaction equation
[NH:1]1[C:9]2[CH:8]=[C:7]([N:10]([C:16]([CH3:23])([CH2:18][C:19]([CH3:22])([CH3:21])[CH3:20])[CH3:17])[C:11]([CH:13]3[CH2:15][CH2:14]3)=[O:12])[N:6]=[CH:5][C:4]=2[CH:3]=[CH:2]1.[Cl:24][C:25]1[CH:33]=[CH:32][CH:31]=[C:30]([Cl:34])[C:26]=1[C:27](Cl)=[O:28].ClC1C=CC=C(Cl)C=1C(N1C2C=CN=CC=2C=C1)=O>>[Cl:24][C:25]1[CH:33]=[CH:32][CH:31]=[C:30]([Cl:34])[C:26]=1[C:27]([N:1]1[C:9]2[CH:8]=[C:7]([N:10]([C:16]([CH3:23])([CH2:18][C:19]([CH3:22])([CH3:21])[CH3:20])[CH3:17])[C:11]([CH:13]3[CH2:14][CH2:15]3)=[O:12])[N:6]=[CH:5][C:4]=2[CH:3]=[CH:2]1)=[O:28]

Participants

4

Reactant 3

HCID 783922,6-Dichlorobenzoyl chlorideHCID 71061561(2,6-dichlorophenyl)(1H-pyrrolo[3,2-c]pyridin-1-yl)methanoneHCID 71061827HCID 71061827, compound

Product 1

HCID 71061760N-[1-(2,6-dichlorobenzoyl)-1H-pyrrolo[3,2-c]pyridin-6-yl]-N-(2,4,4-trimethylpentan-2-yl)cyclopropanecarboxamide

Procedure

The compound was prepared from N-(1H-pyrrolo[3,2-c]pyridin-6-yl)-N-(2,4,4-trimethylpentan-2-yl)cyclopropanecarboxamide and 2,6-dichlorobenzoyl chloride following the procedure same as that of (2,6-dichlorophenyl)(1H-pyrrolo[3,2-c]pyridin-1-yl)methanone

Sources & evidence

ORD record
ord-356383b321fd43618caf15d46ec7b752
Source dataset
uspto-grants-2016_06
Patent number
US09364466B2

Reaction notes

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