HCID 71061827, compound → N-[1-(2,6-dichlorobenzoyl)-1H-pyrrolo[3,2-c]pyridin-6-yl]cyclopropanecarboxamide

HRID 2201878Notes

Reaction equation

HRID 2201878 reaction equation
[Cl:1][C:2]1[CH:24]=[C:23](C#N)[CH:22]=[C:21]([Cl:27])[C:3]=1[C:4]([N:6]1[C:14]2[CH:13]=[C:12]([NH:15][C:16]([CH:18]3[CH2:20][CH2:19]3)=[O:17])[N:11]=[CH:10][C:9]=2[CH:8]=[CH:7]1)=[O:5].N1C2C=C(N(C(C)(CC(C)(C)C)C)C(C3CC3)=O)N=CC=2C=C1.C(C1C=C(Cl)C(C(Cl)=O)=C(Cl)C=1)#N>>[Cl:27][C:21]1[CH:22]=[CH:23][CH:24]=[C:2]([Cl:1])[C:3]=1[C:4]([N:6]1[C:14]2[CH:13]=[C:12]([NH:15][C:16]([CH:18]3[CH2:19][CH2:20]3)=[O:17])[N:11]=[CH:10][C:9]=2[CH:8]=[CH:7]1)=[O:5]

Participants

4

Reactant 3

HCID 71061827HCID 71061827, compoundHCID 71080879N-[1-(2,6-dichloro-4-cyanobenzoyl)-1H-pyrrolo[3,2-c]pyridin-6-yl]cyclopropane carboxamideHCID 866489562,6-Dichloro-4-cyanobenzoyl chloride

Product 1

HCID 71062968N-[1-(2,6-dichlorobenzoyl)-1H-pyrrolo[3,2-c]pyridin-6-yl]cyclopropanecarboxamide

Procedure

N-[1-(2,6-dichloro-4-cyanobenzoyl)-1H-pyrrolo[3,2-c]pyridin-6-yl]cyclopropane carboxamide (Compound No. 137) was prepared from N-(1H-pyrrolo[3,2-c]pyridin-6-yl)-N-(2,4,4-trimethylpentan-2-yl)cyclopropane carboxamide by treating with 4-cyano-2,6-dichlorobenzoyl chloride following a procedure as per step k and l in Example 27.

Sources & evidence

ORD record
ord-5001316cc9b744879c20dc2eff651a52
Source dataset
uspto-grants-2016_06
Patent number
US09364466B2

Reaction notes

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