HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 2201894Generated: October 29, 2026
Dimethylformamide → 1-[(4-Fluorophenyl)carbamoyl]cyclopropanecarbonyl chloride
https://huagongshe.com/reaction/2201894
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Dimethylformamide | HCID 6228 | — |
| Reactant | Oxalyl chloride | HCID 65578 | — |
| Reactant | 1-[(4-Fluorophenyl)carbamoyl]cyclopropanecarboxylic Acid | HCID 21081530 | — |
| Solvent | Tetrahydrofuran | HCID 8028 | — |
| Product | 1-[(4-Fluorophenyl)carbamoyl]cyclopropanecarbonyl chloride | HCID 58083267 | — |
Reaction Steps
A reactor was charged with 1-(4-fluoro-phenylcarbamoyl)-cyclopropanecarboxylic acid (35 kg), 344 g DMF, and 175 kg THF. The reaction mixture was adjusted to 12 to 17° C. and then to the reaction mixture was charged 19.9 kg of oxalyl chloride over a period of 1 hour. The reaction mixture was left stirring at 12 to 17° C. for 3 to 8 hours. This solution was used in the next step without further processing.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| Patent number | US09365516B2 |
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| Source dataset | uspto-grants-2016_06 |
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| ORD ID | ord-0c6e72a1a5db41a88edaf713ea264b61 |
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| Source note | uspto-grants-2016_06 |
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