Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Sodium hydride | HCID 24758 | — |
| Reactant | Benzenepropanoyl chloride | HCID 64801 | — |
| Reactant | 6-Aminoisoquinoline | HCID 588991 | — |
| Solvent | Dimethylformamide | HCID 6228 | — |
| Solvent | Ethyl Acetate | HCID 8857 | — |
| Product | HCID 24999503 | HCID 24999503 | — |
Reaction Steps
To 6-aminoisoquinoline in DMF cooled to 0° C. was added NaH and the solution was stirred for 30 minutes at 0° C. Then hydrocinnamoyl chloride was added and the mixture was stirred for 4 hours at room temperature. The mixture was diluted with EtOAc, extracted with NaHCO3(sat), dried (Na2SO4), filtered and evaporated. Column chromatography (SiO2, 10% hexanes/EtOAc) gave N-(isoquilin-6-yl)-3-phenylpropanamide (E2).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| Patent number | US09365518B2 |
|---|
| Source dataset | uspto-grants-2016_06 |
|---|
| ORD ID | ord-bcf8ffa701b041f8b5f82b8901c07cad |
|---|
| Source note | uspto-grants-2016_06 |
|---|
