HuagongsheHuagongshe Chemistry Print Report · For research reference only
Benzyl isocyanate → 1-Benzyl-3-(isoquinolin-6-yl)urea
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Benzyl isocyanate | HCID 76639 | — |
| Reactant | Sodium Bicarbonate | HCID 516892 | — |
| Reactant | 6-Aminoisoquinoline | HCID 588991 | — |
| Catalyst | 4-(Dimethylamino)pyridine | HCID 14284 | — |
| Solvent | Dimethylformamide | HCID 6228 | — |
| Product | 1-Benzyl-3-(isoquinolin-6-yl)urea | HCID 44276961 | — |
Reaction Steps
To 6-aminoisoquinoline in DMF is added DMAP and benzyl isocyanate and the solution was stirred at room temperature for 4 hours. The mixture was poured into NaHCO3 (sat), extracted with EtOAc, dried (Na2SO4), filtered and evaporated. Flash chromatography (SiO2, 5% MeOH/CH2Cl2) provided 1-benzyl-3-(isoquinolin-6-yl) urea (E88).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US09365518B2 |
| Source dataset | uspto-grants-2016_06 |
| ORD ID | ord-8fd277aea2f044979c25dbac17e66755 |
| Source note | uspto-grants-2016_06 |