HuagongsheHuagongshe Chemistry Print Report · For research reference only
Potassium Carbonate → methyl (4-cyanophenoxy)acetate
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Potassium Carbonate | HCID 11430 | — |
| Reactant | 4-Cyanophenol | HCID 13019 | — |
| Reactant | Methyl bromoacetate | HCID 60984 | — |
| Solvent | Acetonitrile | HCID 6342 | — |
| Product | methyl (4-cyanophenoxy)acetate | HCID 1506457 | — |
Reaction Steps
A mixture of 4-cyanophenol and methyl bromoacetate in CH3CN was treated with K2CO3 and refluxed for 18 hours. Then the reaction was cooled to room temperature and concentrated. The residue was partitioned between EtOAc and H2O and the organic layer was washed with brine, driend (Na2SO4), filtered and evaporated. Flash chromatography (SiO2, hexanes/EtOAc) gave pure methyl 2-(4-cyanophenoxy)acetate.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US09365518B2 |
| Source dataset | uspto-grants-2016_06 |
| ORD ID | ord-4ed6c62478bf4f4c8442c9c326bb613e |
| Source note | uspto-grants-2016_06 |