反应详情

To a solution of 2-(4-bromo-phenyl)-3-(3-diethylamino-pyrrolidin-1-yl)-propionic acid ethyl ester (639 mg, 1.6 mmol) in MeOH (4 mL) was added aq. NaOH (2N, 8 mmol). The solution was stirred at 40 degrees Celsius for 2 h, then concentrated in vacuo. The residue was dissolved in water and neutralized with 2N HCl to pH 5-6 at 0 degrees Celsius. Then the mixture was evaporated to dryness under reduced pressure to obtain a white solid product without further purification. MS: calc'd 369 (MH+), exp 369 (MH+).

1. concentrationconcentrated in vacuo
2. dissolutionThe residue was dissolved in water and neutralized with 2N HCl to pH 5-6 at 0 degrees Celsius
3. customThen the mixture was evaporated to dryness under reduced pressure
4. customto obtain a white solid product
5. customwithout further purification