HuagongsheHuagongshe Chemistry Print Report · For research reference only
Hydrochloric Acid → HCID 78320094, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Hydrochloric Acid | HCID 313 | — |
| Reactant | beta-Alanine, ethyl ester, hydrochloride | HCID 458475 | — |
| Reactant | Methanaminium, N-((dimethylamino)(3H-1,2,3-triazolo(4,5-b)pyridin-3-yloxy)methylene)-N-methyl-, hexafluorophosphate(1-) (1:1) | HCID 9886157 | — |
| Reactant | HCID 78321671 | HCID 78321671 | — |
| Solvent | Dimethylformamide | HCID 6228 | — |
| Product | HCID 78320094 | HCID 78320094 | — |
Reaction Steps
A mixture of (R)-1-(4′-(2-(2-methylpyrrolidin-1-yl)ethyl)biphenyl-4-yl)cyclopentanecarboxylic acid (15 mg, 0.040 mmol), ethyl 3-aminopropanoate hydrochloride (6.71 mg, 0.044 mmol), HATU (16.62 mg, 0.044 mmol), and TEA (0.017 mL, 0.119 mmol) in DMF (0.4 mL) was stirred at room temperature overnight. The mixture was acidified with 1M HCl and purified by HPLC to give the title compound. LCMS m/z=477.5.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US09365511B2 |
| Source dataset | uspto-grants-2016_06 |
| ORD ID | ord-1e8b186d025c4b45b9b3b32246db899f |
| Source note | uspto-grants-2016_06 |